Water sustains societies, economies, and ecosystem services locally and globally. Yet, competition over freshwater is intensifying worldwide, driven by rising demand and shifting availability under climate change and variability. Addressing these challenges requires integrative water management and policy approaches that balance trade-offs across social, economic, and environmental water uses. Equally, adaptive and flexible solutions are needed to allow policies to adapt to changing and uncertain climatic and socio-economic conditions, thereby strengthening the sustainability and resilience of water systems. This session provides a forum for showcasing novel and emerging research at the intersection of agricultural production, energy security, water supply, economic development, and environmental conservation. In particular, we encourage contributions that: (i) advance understanding of critical interconnections, feedbacks, and risks within water system components, (ii) introduce novel methods or tools for evaluating and monitoring trade-offs and performance in water allocation, management, and policy across sectors, (iii) evaluate technological, policy, and/or governance innovations to address the water-food-energy-environment nexus across scales (local, regional, and/or global), and (iv) advance methods to evaluate risks to water systems and identify solutions to enhance system and user resilience. We welcome real-world examples on the successful application of these methods to facilitate integrated planning and management of the water-food-energy-environment (WEFE) nexus.